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Cationic complex: (99m)Tc-N,N'-dimethyldiaminedithiol.

Jae Min Jeong·Yun-Sang Lee·Young Joo Kim·Dong Soo Lee·June-Key Chung·Young-Ger Suh·Myung Chul Lee
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Abstract

Diaminedithiol (DADT) or N-monosubstituted DADT is known to form lipophilic neutral chelates with technetium. As a result, they are used for brain imaging agents. However, 99mTc-N,N'-dimethylDADT has been demonstrated to have a positive charge and a lower lipophilicity (log P = 0.1) in this experiment. The results of a biodistribution study showed that most activity was found in the intestine after 1 hr, which is the evidence of bile excretion. Increased heart-uptake in mice suggests that this compound or its derivatives can be used as a myocardial-imaging agent.

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AnimalsCationsChelating AgentsMaleMiceMice, Inbred ICROrganotechnetium CompoundsRadiopharmaceuticalsSulfur CompoundsTissue DistributionWhole-Body CountingJournal Article

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Jae Min Jeong, Yun-Sang Lee, Young Joo Kim, Dong Soo Lee, June-Key Chung, Young-Ger Suh, Myung Chul Lee. 2002. Cationic complex: (99m)Tc-N,N'-dimethyldiaminedithiol.. https://doi.org/10.1016/s0969-8051(02)00312-8

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