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Virtual mitochondria: metabolic modelling and control.

Marie Aimar-Beurton·Bernard Korzeniewski·Thierry Letellier·Stéphane Ludinard·Jean-Pierre Mazat·Christine Nazaret
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Abstract

Inside the eukaryotic cell, mitochondria are internal organelles of prokaryotic origin, responsible for energy supply in the cell. The control of the mitochondrial ATP production is a complex problem with different patterns according to different tissues and organs. Our aim is to continue to develop the modelling of oxidative phosphorylation in different tissues, to model other parts of mitochondrial metabolism and to include this virtual mitochondria in a virtual cell. In constructing the complete metabolic map of mitochondria, we will take advantage of the sequenced genomes of eukaryotic organism (10-15% of the yeast genome concerns mitochondria).

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AnimalsGenomeHumansMitochondriaMitochondrial ProteinsModels, BiologicalOxidative PhosphorylationPlant ProteinsJournal ArticleResearch Support, Non-U.S. Gov't

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Marie Aimar-Beurton, Bernard Korzeniewski, Thierry Letellier, Stéphane Ludinard, Jean-Pierre Mazat, Christine Nazaret. 2002. Virtual mitochondria: metabolic modelling and control.. https://doi.org/10.1023/a%3A1020338115406

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