Evolution of lipoproteins deduced from protein sequence data.

W C Barker; M O Dayhoff

doi:10.1016/0305-0491(77)90060-8

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Evolution of lipoproteins deduced from protein sequence data.

W C Barker·M O Dayhoff

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Abstract

1. Human serum apolipoprotein A-I contains a prominent 11-residue sequence periodicity. 2. Similar 11-residue segments occur in the other sequenced human apolipoproteins, C-I, C-III, and A-II. 3. Computer analyses of the sequences support the hypothesis that they evolved from a common ancestor. 4. An evolutionary history of these proteins is proposed. 5. The estimated rate of change of these proteins indicates that all four types will be found throughout the vertebrates and that related proteins will also be found in invertebrates.

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Amino Acid Sequence Animals Apolipoprotein A-I Apolipoprotein A-II Apolipoprotein C-I Apolipoprotein C-III Apolipoproteins Apolipoproteins A Apolipoproteins C Biological Evolution Gene Amplification Humans Macaca mulatta Molecular Sequence Data Software Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

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W C Barker, M O Dayhoff. 1977. Evolution of lipoproteins deduced from protein sequence data.. https://doi.org/10.1016/0305-0491(77)90060-8

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