Peptic-ulcer disease.

Francis K L Chan; W K Leung

doi:10.1016/s0140-6736(02)11030-0

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PubMed · 12354485

Peptic-ulcer disease.

Francis K L Chan·W K Leung

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Abstract

The discovery of Helicobacter pylori has greatly changed our approach to peptic ulcer disease. Bacterial, host, and environmental factors all have a role in peptic-ulcer disease. Although the prevalence of uncomplicated peptic ulcers is falling, hospital admissions for ulcer complications associated with non-steroidal anti-inflammatory drugs (NSAIDs) are rising. Evidence suggests that prescription of NSAIDs along with potent antiulcer agents and the use of highly selective cyclo-oxygenase-2 inhibitors reduce gastroduodenal ulceration. Whether these therapeutic advances will translate into clinical benefits remains to be seen. The interaction between H pylori and NSAIDs is one of the most controversial issues in peptic ulcer disease. With the fall in rates of H pylori infection, the proportion of ulcers not related to this organism and NSAIDs has risen, which will affect the management of peptic ulcer.

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Anti-Inflammatory Agents, Non-Steroidal Anti-Ulcer Agents Clinical Trials as Topic Helicobacter Infections Helicobacter pylori Humans Peptic Ulcer Journal Article Review

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Francis K L Chan, W K Leung. 2002-09-21. Peptic-ulcer disease.. https://doi.org/10.1016/s0140-6736(02)11030-0

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