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E2F1 pathways to apoptosis.

Doron Ginsberg
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Abstract

The E2F family of transcription factors plays a pivotal role in the regulation of cell proliferation and their activity is often deregulated in human tumors. Recent studies demonstrate that E2F1 can induce both proliferation and apoptosis. E2F1-induced apoptosis occurs via multiple pathways, some of which induce stabilization and activation of the tumor suppressor p53. The pro-apoptotic activity of E2F1 suggests that its deregulation constitutes an oncogenic stress that may target pre-malignant cells to undergo apoptosis, thus preventing tumor development.

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AnimalsApoptosisCell Cycle ProteinsDNA-Binding ProteinsE2F Transcription FactorsE2F1 Transcription FactorHumansNeoplasmsTranscription FactorsTumor Suppressor Protein p53Journal ArticleResearch Support, Non-U.S. Gov'tReview

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BibTeXRIS

Doron Ginsberg. 2002-10-02. E2F1 pathways to apoptosis.. https://doi.org/10.1016/s0014-5793(02)03270-2

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