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PubMed · 12357695

[Conjugate vaccines].

B Swennen·J Sternon
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Abstract

Conjugate vaccines extend the vaccinal prevention for children to more diseases. Conjugating the capsular polysaccharide to a carrier protein transforms a T-independent antigen in a T-dependent, allowing protection of the children (before 2 years of age) against Haemophilus influenzae type b, meningococcal C and pneumococcal infections. This article reviews the 3 conjugate vaccines and their results with focus on some questions: antigens interference in the immunological response, serological subrogate for protection, herd immunity and replacement of circulating serotypes.

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Haemophilus InfectionsHaemophilus influenzae type bHumansImmunity, CellularPneumococcal InfectionsVaccines, ConjugateEnglish AbstractJournal ArticleReview

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B Swennen, J Sternon. [Conjugate vaccines].. https://pubmed.ncbi.nlm.nih.gov/12357695/

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