Colorimetric SNP analysis using oligonucleotide-modified nanoparticles.

Toshihiro Ihara; Yasushi Chikaura; Shojiro Tanaka; Akinori Jyo

doi:10.1039/b206158a

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Colorimetric SNP analysis using oligonucleotide-modified nanoparticles.

Toshihiro Ihara·Yasushi Chikaura·Shojiro Tanaka·Akinori Jyo

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Abstract

A point mutation in the p53 gene has been detected by means of fluorescence microscopy and fluorescent resonance energy transfer (FRET) through sequence selective aggregation of DNA-modified nanoparticles, in which fluorescent dyes were impregnated.

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Base Sequence Colorimetry DNA Energy Transfer Fluorescent Dyes Genes, p53 Microscopy, Fluorescence Oligonucleotide Probes Particle Size Point Mutation Polymorphism, Single Nucleotide Journal Article Research Support, Non-U.S. Gov't

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Toshihiro Ihara, Yasushi Chikaura, Shojiro Tanaka, Akinori Jyo. 2002-09-21. Colorimetric SNP analysis using oligonucleotide-modified nanoparticles.. https://doi.org/10.1039/b206158a

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