SCAP, an ER sensor that regulates cell cholesterol.

Theodore L Steck; Yvonne Lange

doi:10.1016/s1534-5807(02)00263-0

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SCAP, an ER sensor that regulates cell cholesterol.

Theodore L Steck·Yvonne Lange

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Abstract

Cells keep their cholesterol in balance by sensing its level in the endoplasmic reticulum and transducing this information into the expression of multiple homeostatic genes. Two recent papers from the Brown and Goldstein laboratory provide important new insights into how an integral ER protein, SCAP, mediates this process.

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Animals Cell Membrane Cholesterol DNA-Binding Proteins Endoplasmic Reticulum Gene Expression Regulation Golgi Apparatus Intracellular Membranes Intracellular Signaling Peptides and Proteins Membrane Proteins Point Mutation Protein Binding Protein Conformation Protein Processing, Post-Translational Protein Structure, Tertiary Sterols Transcription Factors Trypsin Journal Article

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Theodore L Steck, Yvonne Lange. 2002. SCAP, an ER sensor that regulates cell cholesterol.. https://doi.org/10.1016/s1534-5807(02)00263-0

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