PTEN function in mammalian cell size regulation.

Stéphanie Backman; Vuk Stambolic; Tak Mak

doi:10.1016/s0959-4388(02)00354-9

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PTEN function in mammalian cell size regulation.

Stéphanie Backman·Vuk Stambolic·Tak Mak

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Abstract

The PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3' kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN is associated with the neurological disorder Lhermitte-Duclos disease. PTEN may regulate cell size through effects on protein translation.

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Animals Cell Differentiation Cell Division Cell Size Hamartoma Syndrome, Multiple Humans Neurons PTEN Phosphohydrolase Phosphoric Monoester Hydrolases Tumor Suppressor Proteins Comparative Study Journal Article Research Support, Non-U.S. Gov't Review

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Stéphanie Backman, Vuk Stambolic, Tak Mak. 2002. PTEN function in mammalian cell size regulation.. https://doi.org/10.1016/s0959-4388(02)00354-9

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