Intrinsically unstructured proteins.

Peter Tompa

doi:10.1016/s0968-0004(02)02169-2

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Intrinsically unstructured proteins.

Peter Tompa

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Abstract

The recent suggestion that the classical structure-function paradigm should be extended to proteins and protein domains whose native and functional state is intrinsically unstructured has received a great deal of support. There is ample evidence that the unstructured state, common to all living organisms, is essential for basic cellular functions; thus it deserves to be recognized as a separate functional and structural category within the protein kingdom. In this review, recent findings are surveyed to illustrate that this novel but rapidly advancing field has reached a point where these proteins can be comprehensively classified on the basis of structure and function.

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Amino Acid Sequence Amino Acids Entropy Hydrophobic and Hydrophilic Interactions Models, Molecular Protein Binding Protein Conformation Protein Denaturation Protein Folding Proteins Static Electricity Structure-Activity Relationship Journal Article Research Support, Non-U.S. Gov't Review

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Peter Tompa. 2002. Intrinsically unstructured proteins.. https://doi.org/10.1016/s0968-0004(02)02169-2

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