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Proinsulin C-peptide--a consensus statement.

A A Sima·G Grunberger·H Jörnvall·J Wahren·C-peptide Study Group
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Abstract

In recent years the physiological role of the proinsulin C-peptide has received increasing attention, focusing on the potential therapeutic value of C-peptide replacement in preventing and ameliorating type 1 diabetic complications. In order to consolidate these new data and to identify the immediate directions of C-peptide research and its clinical usefulness, an International Symposium was held in Detroit, Michigan, on October 20-21, 2000, under the auspices of the Wayne State University/Morris Hood Jr. Comprehensive Diabetes Center. In this communication, we review the cellular, physiological and clinical effects of C-peptide replacement in animal models and in patients with type 1 diabetes. Finally, recommendations are presented as to the most urgent studies that should be pursued to further establish the biological action of C-peptide and its therapeutic value.

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ApoptosisC-PeptideClinical Trials as TopicDiabetes MellitusHumansProinsulinSodium-Potassium-Exchanging ATPaseConsensus StatementJournal ArticleResearch Support, Non-U.S. Gov'tReview

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A A Sima, G Grunberger, H Jörnvall, J Wahren, C-peptide Study Group. 2001. Proinsulin C-peptide--a consensus statement.. https://doi.org/10.1155/edr.2001.145

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