Peptides neutralizing lipopolysaccharide - structure and function.

P Pristovsek; J Kidric

doi:10.2174/1389557013406729

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Peptides neutralizing lipopolysaccharide - structure and function.

P Pristovsek·J Kidric

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Abstract

Lipopolysaccharide (LPS) induced Gram-negative sepsis and septic shock remain lethal in up to 60 % of cases, and LPS antagonists that neutralize its endotoxic action are the subject of intensive research. In the last decade peptidic antagonists have become increasingly important in providing leads for treatment of LPS-mediated diseases. In this review an overview of the sources, functions and structures of antiseptic and antibacterial peptides that interact with LPS is presented.

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Amino Acid Sequence Animals Endotoxins Humans Lipopolysaccharides Molecular Sequence Data Peptides Shock, Septic Signal Transduction Structure-Activity Relationship Journal Article Review

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P Pristovsek, J Kidric. 2001. Peptides neutralizing lipopolysaccharide - structure and function.. https://doi.org/10.2174/1389557013406729

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