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PubMed · 1237103

Neurofibrillary changes after acute experimental lead poisoning.

W J Niklowitz
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Abstract

Following acute tetraethyllead intoxication in rabbits classic neurofibrillary tangles develop. As studied by electron microscopy, such tangles develop in hydropic degenerating neurons and consist primarily of bundles of 200 A diameter smooth tubules of enormous length. In two of 16 animals a few twisted tubules (periodicity of 800 A) also could be found. The significance of these lead-induced twisted tubules, so characteristic of Alzheimer's pre-senile dementia in man, is discussed.

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Acute DiseaseAnimalsBrainCerebellar CortexFrontal LobeHippocampusLead PoisoningMaleMicrotubulesNeurofibrilsRabbitsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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BibTeXRIS

W J Niklowitz. 1975. Neurofibrillary changes after acute experimental lead poisoning.. https://doi.org/10.1212/wnl.25.10.927

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