Desmosomes and disease: an update.

M Chidgey

doi:10.14670/hh-17.1179

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Desmosomes and disease: an update.

M Chidgey

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Abstract

Desmosomes play a critical role in the maintenance of normal tissue architecture. Skin blistering can occur when desmosomal adhesion is compromised by antibodies in autoimmune diseases such as pemphigus. Inherited mutations in genes encoding desmosomal constituents can adversely affect the skin, and result in heart abnormalities. Desmosomes may have a tumour suppressor function: expression of desmosomal components is reduced in some human cancers, and desmosomal cadherins have the capacity to suppress the invasiveness of cells in culture. Transgenic animal research has provided important insights into the role of these junctions in normal epithelial morphogenesis and disease.

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Animals Cadherins Desmosomes Humans Neoplasms Pemphigus, Benign Familial Skin Diseases Skin Physiological Phenomena Journal Article Research Support, Non-U.S. Gov't Review

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M Chidgey. 2002. Desmosomes and disease: an update.. https://doi.org/10.14670/hh-17.1179

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