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PubMed · 12371622

The TCR/CD3 complex: molecular interactions in a changing structure.

Maria José Feito·Arturo Jiménez-Periañez·Gloria Ojeda·Alejandra Sánchez·Pilar Portolés·José M Rojo
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Abstract

The T cell receptor-CD3 (TCR/CD3) complex is a multichain structure in charge of antigen recognition in T cells. Despite many genetic, structural, and functional data obtained in recent years, essential questions concerning the TCR/CD3 complex still remain open, including: 1) the precise number of polypeptides in each TCR/CD3 complex, their interactions and spatial arrangement, 2) the role(s) of each polypeptide in antigen recognition and/or in receptor signal transmission, and 3) the relationship between the TCR/CD3 complex and other membrane or cytoplasmic molecules involved in downstream signaling. In this work we shall review data concerning some of these issues, proposing a model of the overall structure of the TCR/CD3 complex to explain its known features.

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AnimalsHumansModels, MolecularProtein BindingProtein ConformationProtein SubunitsReceptor-CD3 Complex, Antigen, T-CellJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Maria José Feito, Arturo Jiménez-Periañez, Gloria Ojeda, Alejandra Sánchez, Pilar Portolés, José M Rojo. 2002. The TCR/CD3 complex: molecular interactions in a changing structure.. https://pubmed.ncbi.nlm.nih.gov/12371622/

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