Nitric oxide synthesis is involved in arterial haptoglobin expression after sustained flow changes.

Mirjam B Smeets; Gerard Pasterkamp; Sai-Kiang Lim; Evelyn Velema; Ben van Middelaar; Dominique P V de Kleijn

doi:10.1016/s0014-5793(02)03343-4

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Nitric oxide synthesis is involved in arterial haptoglobin expression after sustained flow changes.

Mirjam B Smeets·Gerard Pasterkamp·Sai-Kiang Lim·Evelyn Velema·Ben van Middelaar·Dominique P V de Kleijn

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Abstract

The acute phase protein haptoglobin is highly expressed in arteries after sustained flow changes and involved in cell migration and arterial restructuring. In the liver, haptoglobin expression is mainly regulated by interleukin-6 (IL-6). In the artery, shear stress and NO influence IL-6 expression. In the present study, we demonstrate that NO synthesis is involved in the regulation of arterial haptoglobin expression after sustained flow changes. Decreased haptoglobin expression after NO inhibition coincided with decreased IL-6 levels. However, IL-6 knockout mice had normal arterial haptoglobin expression levels after sustained flow changes suggesting that other mediators may provide compensatory mechanisms for the regulation of arterial haptoglobin expression.

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Animals Arteries Base Sequence DNA Primers Haptoglobins Interleukin-6 Mice Mice, Knockout NG-Nitroarginine Methyl Ester Nitric Oxide Rabbits Regional Blood Flow Journal Article Research Support, Non-U.S. Gov't

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Mirjam B Smeets, Gerard Pasterkamp, Sai-Kiang Lim, Evelyn Velema, Ben van Middelaar, Dominique P V de Kleijn. 2002-10-09. Nitric oxide synthesis is involved in arterial haptoglobin expression after sustained flow changes.. https://doi.org/10.1016/s0014-5793(02)03343-4

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