Urinary complement factor H in renal disease.

Mariko Tamano; Yoshinobu Fuke; Morito Endo; Isao Ohsawa; Takayuki Fujita; Hiroyuki Ohi

doi:10.1159/000064090

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Urinary complement factor H in renal disease.

Mariko Tamano·Yoshinobu Fuke·Morito Endo·Isao Ohsawa·Takayuki Fujita·Hiroyuki Ohi

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Abstract

BACKGROUND: Complement factor H (hCFH) plays a key inhibitory role in the control of the alternative complement pathway. We examined whether urinary hCFH (U-hCFH) levels is useful as an indirect indicator of renal damage. METHODS: Urine samples were obtained from 104 patients with renal disease. Urine was collected with 10 mM EDTA and U-hCFH levels were measured using the BTA TRAK Assay Kit. RESULTS: In the 62 patients with nephritis, the levels of U-hCFH were elevated (range 15-52,198 U/ml) over the normal range (0-14 U/ml). U-hCFH levels of patients with chronic renal failure, lupus nephritis, membranoproliferative glomerulonephritis, focal glomerulosclerosis were higher than that of IgA nephropathy patients (p < 0.05). In the patients with minimal change disease, showed high levels of U-hCFH during the nephrotic syndrome. U-hCFH was correlated significantly with urinary protein and urinary N-acetyl-beta-D-glucosaminidase. CONCLUSIONS: We demonstrated that U-hCFH was detected in the urine of nephritis patients.

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Biomarkers Complement Activation Complement Factor H Female Glomerulonephritis, Membranoproliferative Humans Lupus Nephritis Male Middle Aged Nephritis, Interstitial Nephrosis, Lipoid Journal Article

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Mariko Tamano, Yoshinobu Fuke, Morito Endo, Isao Ohsawa, Takayuki Fujita, Hiroyuki Ohi. 2002. Urinary complement factor H in renal disease.. https://doi.org/10.1159/000064090

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