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Extended-release methylphenidate (Ritalin LA).

Katherine A Lyseng-Williamson·Gillian M Keating
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Abstract

An extended-release formulation of methylphenidate (Ritalin LA), a CNS stimulant that inhibits dopamine and noradrenaline (norepinephrine) reuptake into presynaptic neurons, has been developed for use in patients with attention deficit/hyperactivity disorder (ADHD). In children with ADHD and healthy male adults, extended-release methylphenidate 20mg was rapidly absorbed and demonstrated two distinct peak plasma concentrations approximately 4 hours apart. The absorption pharmacokinetics of extended-release methylphenidate 20mg, which closely mimics those of immediate-release methylphenidate 10mg given in two doses 4 hours apart, permits once-daily administration. In a 2-week randomised, double-blind, placebo-controlled trial in 134 evaluable children aged 6 to 12 years with ADHD, symptoms improved to a significantly greater extent with extended-release methylphenidate 10 to 40mg once daily than with placebo. Extended-release methylphenidate improved both inattention and hyperactivity symptoms and was effective in children with combined- (inattentive and hyperactive/impulsive) type or predominantly inattentive-type ADHD. In clinical trials, the safety and tolerability profiles of extended-release methylphenidate were consistent with that of the immediate-release formulation.

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Administration, OralAdultAttention Deficit Disorder with HyperactivityChildDelayed-Action PreparationsDopamine Uptake InhibitorsHumansMethylphenidateRandomized Controlled Trials as TopicTreatment OutcomeJournal ArticleReview

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BibTeXRIS

Katherine A Lyseng-Williamson, Gillian M Keating. 2002. Extended-release methylphenidate (Ritalin LA).. https://doi.org/10.2165/00003495-200262150-00012

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