[Relationship between apoptotic activity and radiosensitivity in solid tumors: does apoptosis always bring good clinical results?].

Masahiko Miura

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PubMed · 12391683

[Relationship between apoptotic activity and radiosensitivity in solid tumors: does apoptosis always bring good clinical results?].

Masahiko Miura

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Abstract

Apoptosis has recently been considered to be a predictor of tumor response or outcome following chemotherapy or radiotherapy. Although apoptosis clearly occurs in the very early stages following such treatments, it is unclear whether its frequency correlates with the likelihood of tumor cure following radiotherapy, especially in solid tumors, where the major mode of cell death is necrosis. This review discuses the relationship between apoptotic activity and radiosensitivity or tumor response from various points of view, including experimental systems and clinical conditions.

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Animals Apoptosis Dose-Response Relationship, Radiation Humans Neoplasms Radiation Tolerance Tumor Cells, Cultured Tumor Suppressor Protein p53 English Abstract Journal Article Review

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Masahiko Miura. 2002. [Relationship between apoptotic activity and radiosensitivity in solid tumors: does apoptosis always bring good clinical results?].. https://pubmed.ncbi.nlm.nih.gov/12391683/

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