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Developmental changes in lysosome morphology and function Leishmania parasites.

Ross F Waller·Malcolm J McConville
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Abstract

The endocytic pathway of Leishmania parasites has recently come under intense research focus through the development of several markers for various compartments of this pathway. Through these studies a novel multivesicular tubule lysosome has been discovered in promastigote-stage parasites. This organelle has a highly dynamic role during parasite growth and differentiation. This review discusses recent insights into the Leishmania lysosome with respect to its organisation within the endocytic pathway, stage-specific functions, and biogenesis.

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AnimalsBiological Transport, ActiveEndocytosisLeishmaniaLysosomesProtozoan ProteinsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Ross F Waller, Malcolm J McConville. 2002. Developmental changes in lysosome morphology and function Leishmania parasites.. https://doi.org/10.1016/s0020-7519(02)00140-6

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