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Hemoglobin-based oxygen carriers.

Christopher P Stowell
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Abstract

Three types of materials have been studied as candidate blood substitutes: the perfluorocarbons, modified hemoglobins, and liposome-encapsulated hemoglobin. Progress has been greatest with the hemoglobin-based oxygen carriers. Hemoglobin is a highly active molecule; hence, modification has been required to avoid potential deleterious effects. Although there has been considerable progress toward bringing such a product to the clinic, its development has challenged understanding of oxygen delivery and use. The study of these molecules has provided new insights into basic physiologic processes.

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AnimalsBlood SubstitutesClinical Trials as TopicHemoglobinsHumansOxygenTreatment OutcomeJournal ArticleReview

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Christopher P Stowell. 2002. Hemoglobin-based oxygen carriers.. https://doi.org/10.1097/00062752-200211000-00013

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