Modelling large scale neuronal networks using 'average neurones'.

Tibor I Tóth; Vincenzo Crunelli

doi:10.1097/00001756-200210070-00018

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Modelling large scale neuronal networks using 'average neurones'.

Tibor I Tóth·Vincenzo Crunelli

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Abstract

Large scale neuronal network models have become important tools in studying the information transmission within the CNS. In most cases, these models use simplifying assumptions because of unavailable data (e.g. unknown exact network connectivity), and for technical reasons (to preserve numerical stability of the model). Here, we present a novel approach, based on a probabilistic connectivity principle, to this modelling problem for which no knowledge of the exact network connectivity is required. This principle makes it sufficient to compute only the typical neuronal behaviour, represented by 'average neurones', in the network. As a consequence, detailed neurone models can be employed without seriously compromising computational efficiency. Our model thus provides a viable alternative to deterministic models.

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Action Potentials Animals Central Nervous System Humans Ion Channels Models, Statistical Nerve Net Neural Inhibition Neural Networks, Computer Neural Pathways Neurons Receptors, AMPA Receptors, GABA Receptors, N-Methyl-D-Aspartate Synaptic Transmission Journal Article Research Support, Non-U.S. Gov't

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Tibor I Tóth, Vincenzo Crunelli. 2002-10-07. Modelling large scale neuronal networks using 'average neurones'.. https://doi.org/10.1097/00001756-200210070-00018

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