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PubMed · 12407420

Post-intervention vessel remodeling.

J Rutanen·H Puhakka·S Ylä-Herttuala
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Abstract

By-pass surgery and percutaneous transluminal (coronary) angioplasty, PT(C)A, are standard techniques for the treatment of vascular occlusions. Their usefulness is limited by by-pass graft failure and restenosis occurring after the procedures. Twenty percent of patients treated with PTCA/PTA need a new revascularization procedure within 6 months, despite a successful procedure. Stents are used to prevent restenosis in selected lesions, but in-stent restenosis also remains an important clinical problem. In this review we discuss progress of gene therapy for the treatment of post-PT(C)A restenosis, in-stent restenosis and by-pass graft stenosis over the last 2 years (2000-2002).

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AnimalsCoronary DiseaseCoronary RestenosisEndothelial Growth FactorsGenetic TherapyGraft Occlusion, VascularHumansHyperplasiaModels, AnimalMyocardial RevascularizationOligonucleotides, AntisenseProto-Oncogene Proteins c-mycTransduction, GeneticTunica IntimaVascular Endothelial Growth Factor AJournal ArticleResearch Support, Non-U.S. Gov'tReview

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J Rutanen, H Puhakka, S Ylä-Herttuala. 2002. Post-intervention vessel remodeling.. https://doi.org/10.1038/sj.gt.3301866

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