Molecular complexes formed with polycystins.

Montaha Lakkis; Jing Zhou

doi:10.1159/000066648

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Molecular complexes formed with polycystins.

Montaha Lakkis·Jing Zhou

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Abstract

Polycystins are a family of novel transmembrane proteins with at least six members already identified in humans. Defects in polycystins-1 and -2 are responsible for nearly all cases of autosomal-dominant polycystic kidney disease (ADPKD), a major cause of end-stage renal failure. With the progress made in elucidating the genetic basis of ADPKD, the challenges are to understand the functions of polycystins and to delineate the biochemical and cellular mechanisms of cyst development and progression. In this review, we summarize the recent advances in our knowledge of the functions of polycystins with emphasis on the molecular composition of polycystin protein complexes in the kidney.

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Animals Calcium Channels Humans Macromolecular Substances Membrane Glycoproteins Membrane Proteins Phosphoproteins Polycystic Kidney, Autosomal Dominant Proteins Receptors, Cell Surface TRPP Cation Channels Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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Montaha Lakkis, Jing Zhou. 2003. Molecular complexes formed with polycystins.. https://doi.org/10.1159/000066648

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