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PubMed · 12415264

CD1-dependent dendritic cell instruction.

Michael S Vincent·David S Leslie·Jenny E Gumperz·Xiaowei Xiong·Ethan P Grant·Michael B Brenner
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Abstract

Both microbial products and T cell factors influence dendritic cell (DC) maturation. However, it is not known which T cells are capable of interacting with DCs at the initiation of adaptive immunity, when foreign antigen-specific T cells are rare. We show here that self-reactive CD1-restricted T cells can promote DC maturation by recognizing CD1 in the absence of foreign antigens. T cell recognition of all four CD1 isoforms can trigger DC maturation, but their distinct mechanisms of costimulation lead to profound differences in concomitant interleukin 12 p70 production. Distinct CD1-reactive T cells may thus differentially direct DC development early in the immune response, thereby controlling subsequent polarization of acquired immunity.

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Antigens, CD1Cell CommunicationCell DifferentiationDendritic CellsHumansImmunity, CellularT-LymphocytesJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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Michael S Vincent, David S Leslie, Jenny E Gumperz, Xiaowei Xiong, Ethan P Grant, Michael B Brenner. 2002-11-04. CD1-dependent dendritic cell instruction.. https://doi.org/10.1038/ni851

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