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A positive look at double-negative thymocytes.

Rod Ceredig·Ton Rolink
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Abstract

In some respects, our understanding of the cellular and molecular aspects of early T-cell differentiation is lagging behind that of B cells. Papers describing gene-knockout and reporter-transgenic mice in which thymocyte development is affected are often difficult to interpret. Progress in this field will be hampered unless a more detailed phenotypic and molecular analysis of progenitor thymocytes at the single-cell level is carried out.

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AnimalsCD4 AntigensCD8 AntigensGene Rearrangement, T-LymphocyteHematopoietic Stem CellsHumansImmunophenotypingLymphocyte CountProto-Oncogene Proteins c-kitT-LymphocytesJournal ArticleReview

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Rod Ceredig, Ton Rolink. 2002. A positive look at double-negative thymocytes.. https://doi.org/10.1038/nri937

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