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PubMed · 12421724

Genetics--cellular basis.

Andrea Buda·Massimo Pignatelli
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Abstract

Colorectal carcinogenesis is a multistep process during which the specialised epithelial cells of intestinal mucosa surface (e.g. colonocytes) accumulate a series of genetic and epigenetic events which lead to a perturbation of their normal cellular functions and turnover. This review will address the mechanisms and biological effects of these abnormalities on the growth control, differentiation, adhesion and survival of the colonocytes.

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AnimalsCadherinsCell AdhesionCell DifferentiationColorectal NeoplasmsCytoskeletal ProteinsGenes, APCHumansIntestinal MucosaMutationProto-Oncogene ProteinsSignal TransductionTrans-ActivatorsTransforming Growth Factor betaWnt ProteinsZebrafish Proteinsbeta CateninJournal ArticleReview

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Andrea Buda, Massimo Pignatelli. 2002. Genetics--cellular basis.. https://doi.org/10.1093/bmb%2F64.1.45

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