Protein-cleaving catalyst selective for protein substrate.

Joong Won Jeon; Sang Jun Son; Chang Eun Yoo; In Seok Hong; Jung Bae Song; Junghun Suh

doi:10.1021/ol0269300

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Protein-cleaving catalyst selective for protein substrate.

Joong Won Jeon·Sang Jun Son·Chang Eun Yoo·In Seok Hong·Jung Bae Song·Junghun Suh

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Abstract

A protein-cleaving catalyst specific for a disease-related protein can be used as a catalytic drug. As the first protein-cleaving catalyst selective for a protein substrate, a catalyst for myoglobin was designed by attaching Cu(II) or Co(III) complex of cyclen to a binding site searched by a combinatorial method using peptide nucleic acid monomers as building units. [reaction: see text]

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Base Sequence Binding Sites Catalysis Combinatorial Chemistry Techniques Indicators and Reagents Kinetics Peptide Nucleic Acids Proteins Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Substrate Specificity Journal Article Research Support, Non-U.S. Gov't

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Joong Won Jeon, Sang Jun Son, Chang Eun Yoo, In Seok Hong, Jung Bae Song, Junghun Suh. 2002-11-14. Protein-cleaving catalyst selective for protein substrate.. https://doi.org/10.1021/ol0269300

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