[Vitamin E status in hypercholesterolemic children].

Magdalena Chelchowska; Teresa Laskowska-Klita; Barbara Radomyska

PubMed · 12426457

[Vitamin E status in hypercholesterolemic children].

Magdalena Chelchowska·Teresa Laskowska-Klita·Barbara Radomyska

Abstract

The prime role of oxidized low-density lipoprotein in the pathogenesis of atherosclerosis is almost universally accepted. Fat soluble antioxidant vitamin E associated with lipoproteins, appears to have antiatheroma properties. In the presented studies concentration of vitamin E and the relationship between tocopherol and lipids were studied in blood of hypercholesterolemic children. Level of vitamin E was determined by high-performance liquid chromatography (HPLC) method. Compared with normocholesterolemic children, hypercholesterolemic patients had a significantly lower red blood cell vitamin E content (2.55 +/- 0.19 micromol/l vs 3.15+/- 0.33 micromol/l; p<0.005) in spite of their higher plasma vitamin E concentration (27.9 +/- 8.3 micromol/l vs 21.01 +/- 3.6 micromol/l; pl;0.001). In the group of patient tocopherol-to-total cholesterol and tocopherol-to-lipids ratio was statistically lower compared to those in the control group. In hypecholesterolemic children vitamin E positively correlated with total cholesterol (r=0.43; p<0.02), LDL-C (low-density lipoprotein cholesterol) (r=0.42; p<0.02) and lipids (triglycerides + total cholesterol) (r=0.45; p<0.02). This study demonstrates that total plasma vitamin E concentration is not a suitable predictor of cell vitamin E status. Our results suggested that the tocopherol of erythrocytes and vitamin E to lipids ratio in plasma, could be more meaningful indicators to evaluate the vitamin E status in hypercholesterolemic children.

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Adolescent Antioxidants Case-Control Studies Child Child, Preschool Cholesterol, HDL Cholesterol, LDL Chromatography, High Pressure Liquid Female Humans Hypercholesterolemia Male Triglycerides Vitamin E Vitamin E Deficiency English Abstract Journal Article

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Magdalena Chelchowska, Teresa Laskowska-Klita, Barbara Radomyska. [Vitamin E status in hypercholesterolemic children].. https://pubmed.ncbi.nlm.nih.gov/12426457/

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