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BAFF AND APRIL: a tutorial on B cell survival.

Fabienne Mackay·Pascal Schneider·Paul Rennert·Jeffrey Browning
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Abstract

BAFF, a member of the TNF family, is a fundamental survival factor for transitional and mature B cells. BAFF overexpression leads to an expanded B cell compartment and autoimmunity in mice, and elevated amounts of BAFF can be found in the serum of autoimmune patients. APRIL is a related factor that shares receptors with BAFF yet appears to play a different biological role. The BAFF system provides not only potential insight into the development of autoreactive B cells but a relatively simple paradigm to begin considering the balancing act between survival, growth, and death that affects all cells.

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AnimalsAutoimmunityB-Cell Activating FactorB-Cell Activation Factor ReceptorB-LymphocytesCell SurvivalDisease Models, AnimalHumansImmune ToleranceImmunoglobulin ALigandsMembrane ProteinsMiceMice, TransgenicReceptors, Tumor Necrosis FactorSignal TransductionTumor Necrosis Factor Ligand Superfamily Member 13Tumor Necrosis Factor-alphaJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Fabienne Mackay, Pascal Schneider, Paul Rennert, Jeffrey Browning. 2001-12-19. BAFF AND APRIL: a tutorial on B cell survival.. https://doi.org/10.1146/annurev.immunol.21.120601.141152

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