Immunotherapy for allergic asthma.

Abstract

Specific allergen immunotherapy is an effective treatment of allergic asthma. Double-blind studies provide proof of benefit, although seasonal or intermittent asthma consistently responds better than perennial asthma. Advantages of immunotherapy compared with most pharmacotherapies include modification of the natural history of allergic disease, reduction of need for chronic medication, and treatment of both upper and lower airway disease simultaneously. Improvements in immunotherapy occurred in the later portion of the twentieth century because of enhanced understanding of immunotherapy's mechanism of action, recognition of the dose effect, and improved quality and consistency of allergen vaccines. Purified inhibitors of specific mediators of the allergic response, products of biotechnology, will probably lead to improvements of immunotherapy of asthma in the twenty-first century. The future of immunotherapy and other immunomodulation of allergic asthma is promising.