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Prostaglandin E synthase.

Makoto Murakami·Yoshihito Nakatani·Toshihiro Tanioka·Ichiro Kudo
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Abstract

Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG)H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions. Cytosolic PGES (cPGES) is a cytosolic protein that is constitutively expressed in a wide variety of cells and tissues and is associated with heat shock protein 90 (Hsp90). Membrane-associated PGES (mPGES), the expression of which is stimulus-inducible and is downregulated by anti-inflammatory glucocorticoids, is a perinuclear protein belonging to the microsomal glutathione S-transferase (GST) family. These two PGESs display distinct functional coupling with upstream COXs in cells; cPGES is predominantly coupled with the constitutive COX-1, whereas mPGES is preferentially linked with the inducible COX-2. Several cytosolic GSTs also have the capacity to convert PGH2 to PGE2 in vitro. Accumulating evidence has suggested that mPGES participates in various pathophysiological states in which COX-2 is involved, implying that mPGES represents a potential novel target for drug development.

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Alzheimer DiseaseAmino Acid SequenceAnimalsArachidonic AcidBone and BonesCyclooxygenase 2FeverGlutathione TransferaseHumansInflammationIntramolecular OxidoreductasesIsoenzymesMembrane ProteinsMolecular Sequence DataNeoplasmsPainProstaglandin-E SynthasesProstaglandin-Endoperoxide SynthasesReproductionSequence AlignmentJournal ArticleReview

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Makoto Murakami, Yoshihito Nakatani, Toshihiro Tanioka, Ichiro Kudo. 2002. Prostaglandin E synthase.. https://doi.org/10.1016/s0090-6980(02)00043-6

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