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PubMed · 12456305

Creating polyketide diversity through genetic engineering.

James T Kealey
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Abstract

Modular polyketide synthases (PKS) are large multifunctional enzymes that synthesize complex polyketides, a therapeutically important class of natural products. The linear order and composition of catalytic sites that comprise the PKS represent a "code" that determines the identity of the polyketide product. By re-programming the PKS through genetic engineering, it is possible to alter the code in a predictable manner to create specific structural modifications of polyketides and to produce new libraries of these natural products.

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Carbohydrate SequenceEpothilonesErythromycinMolecular StructureMultienzyme ComplexesPeptidesProtein EngineeringRibosomal ProteinsSirolimusJournal ArticleReview

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James T Kealey. 2003-01-01. Creating polyketide diversity through genetic engineering.. https://doi.org/10.2741/885

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