Insulin feedback action on pancreatic beta-cell function.

Ingo B Leibiger; Barbara Leibiger; Per-Olof Berggren

doi:10.1016/s0014-5793(02)03627-x

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Insulin feedback action on pancreatic beta-cell function.

Ingo B Leibiger·Barbara Leibiger·Per-Olof Berggren

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Abstract

Pancreatic beta-cell function is essential for the regulation of glucose homeostasis and its impairment leads to diabetes mellitus. Besides glucose, the major nutrient factor, inputs from neural and humoral components and intraislet cell-cell communication act together to guarantee an appropriate pancreatic beta-cell function. Data obtained over the last 5 years in several laboratories have revitalized a controversial concept, namely the autocrine feedback action of secreted insulin on beta-cell function. While, historically, insulin was suggested to exert a negative effect on beta-cells, recent data provide evidence for a positive role of insulin in transcription, translation, ion flux, insulin secretion and beta-cell survival.

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Animals Autocrine Communication Calcium Feedback, Physiological Humans Insulin Insulin Secretion Ion Transport Islets of Langerhans Mice Protein Biosynthesis Rats Transcription, Genetic Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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Ingo B Leibiger, Barbara Leibiger, Per-Olof Berggren. 2002-12-04. Insulin feedback action on pancreatic beta-cell function.. https://doi.org/10.1016/s0014-5793(02)03627-x

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