Oncolytic viruses.

E Antonio Chiocca

doi:10.1038/nrc948

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PubMed · 12459732

Oncolytic viruses.

E Antonio Chiocca

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Abstract

Although the cytotoxic effects of viruses are usually viewed in terms of pathogenicity, it is possible to harness this activity for therapeutic purposes. Viral genomes are highly versatile, and can be modified to direct their cytotoxicity towards cancer cells. These viruses are known as oncolytic viruses. How are viruses engineered to become tumour specific, and can they be used to safely treat cancer in humans?

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Animals Antineoplastic Agents Cell- and Tissue-Based Therapy Clinical Trials as Topic Genetic Engineering Humans Neoplasms Organ Specificity Virus Physiological Phenomena Virus Replication Viruses Journal Article Review

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E Antonio Chiocca. 2002. Oncolytic viruses.. https://doi.org/10.1038/nrc948

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