uPAR: a versatile signalling orchestrator.

Francesco Blasi; Peter Carmeliet

doi:10.1038/nrm977

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PubMed · 12461559

uPAR: a versatile signalling orchestrator.

Francesco Blasi·Peter Carmeliet

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Abstract

The plasminogen system has been implicated in clot lysis, wound healing, tissue regeneration, cancer and many other processes that affect health and disease. The urokinase receptor uPAR was originally thought to assist the directional invasion of migrating cells, but it is now becoming increasingly evident that this proteinase receptor elicits a plethora of cellular responses that include cellular adhesion, differentiation, proliferation and migration in a non-proteolytic fashion.

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Animals Cell Adhesion Cell Differentiation Cell Division Cell Movement Gene Targeting Humans Integrins Models, Biological Neoplasms Neovascularization, Pathologic Plasminogen Activators Receptors, Cell Surface Receptors, Urokinase Plasminogen Activator Signal Transduction Urokinase-Type Plasminogen Activator Journal Article Research Support, Non-U.S. Gov't Review

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Francesco Blasi, Peter Carmeliet. 2002. uPAR: a versatile signalling orchestrator.. https://doi.org/10.1038/nrm977

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