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Family-based association tests for quantitative traits using pooled DNA.

Joel S Bader·Pak Sham
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Abstract

Interest in whole-genome QTL mapping has spurred efforts to reduce the cost of studies now based primarily on individual genotyping. Pooled DNA tests are a possible solution, and understanding how measurement error affects test power could assist in study design. Here we describe pooled tests explicitly optimised for measurement error, including family-based tests robust to population stratification. Our results suggest that pooled DNA whole-genome screens may be feasible with current instruments.

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Chromosome MappingDNAFemaleGene FrequencyGenome, HumanHumansMaleQuantitative Trait LociJournal Article

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Joel S Bader, Pak Sham. 2002. Family-based association tests for quantitative traits using pooled DNA.. https://doi.org/10.1038/sj.ejhg.5200893

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