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Zolmitriptan: differences from sumatriptan.

P J Goadsby·C J Boes
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Abstract

Zolmitriptan is a potent 5-HT(1B/1D) agonist whose targets include the peripheral and central components of the trigeminovascular system. It is generally well-tolerated and has dose-dependent efficacy in the treatment of migraine. The 2.5 mg dose is felt to provide the best balance between efficacy and adverse events. In a direct comparative study, the 2 h headache response rate for zolmitriptan 2.5 mg was statistically superior to sumatriptan 25 and 50 mg, although at 3.3% not clinically significant. Two comparative studies have found no difference in adverse event frequency between zolmitriptan and sumatriptan.

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Cluster HeadacheHumansMigraine DisordersOxazolidinonesSerotonin Receptor AgonistsSumatriptanTryptaminesJournal ArticleResearch Support, Non-U.S. Gov'tReview

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P J Goadsby, C J Boes. 2001. Zolmitriptan: differences from sumatriptan.. https://doi.org/10.1185/0300799039117013

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