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Eletriptan: pharmacological differences and clinical results.

N Giffin
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Abstract

The potential advantages of eletriptan lie firstly in its lipophilicity reflected as an increased rate of absorption and Tmax compared to sumatriptan. This is manifested in a modest advantage over sumatriptan in terms of speed of onset, 2 h headache response and 2 h pain free. However, eletriptan has not yet been shown to have an advantage over the other triptans for lack of head-to head comparisons. It does not appear to have an advantage over sumatriptan for headache recurrence. The second advantage is the partial agonist activity at the 5-HT(1B) receptor, reducing the potential for cardiovascular side-effects compared to the other triptans. Although no serious cardiovascular events have yet been recognized, eletriptan should still be used with extreme caution for patients with cardiovascular risk factors.

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HumansIndolesMigraine DisordersPyrrolidinesSerotonin Receptor AgonistsSumatriptanTryptaminesJournal ArticleReview

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BibTeXRIS

N Giffin. 2001. Eletriptan: pharmacological differences and clinical results.. https://doi.org/10.1185/0300799039117004

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