Collagen stability, hydration and native state.

Inés G Mogilner; Graciela Ruderman; J Raúl Grigera

doi:10.1016/s1093-3263(02)00145-6

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Collagen stability, hydration and native state.

Inés G Mogilner·Graciela Ruderman·J Raúl Grigera

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Abstract

Molecular dynamics simulations of a collagen-like peptide (Pro-Hyp-Gly)4-Pro-Hyp-Ala-(Pro-Hyp-Gly)5 have been done in order to study the contribution of the hydration structure on keeping the native structure of collagen. The simulation shows that the absence of water produces a distortion on the molecular conformation and an increase in the number of intra-molecular hydrogen bonds. This is in agreement with previous experimental results showing the stiffness of collagen under severe drying and its increase in the thermal stability. This dehydrated material does not keep, however, the native structure.

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Amino Acids Collagen Computer Simulation Crystallography, X-Ray Drug Stability Hydrogen Bonding Models, Molecular Peptides Protein Conformation Repetitive Sequences, Amino Acid Water Comparative Study Journal Article Research Support, Non-U.S. Gov't

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Inés G Mogilner, Graciela Ruderman, J Raúl Grigera. 2002. Collagen stability, hydration and native state.. https://doi.org/10.1016/s1093-3263(02)00145-6

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