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PubMed · 12464559

RNA interference of HIV replication.

Miguel Angel Martínez·Bonaventura Clotet·José A Esté
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Abstract

Double-stranded RNA-mediated interference (RNAi) induces sequence-specific post-transcriptional gene silencing and has emerged as a powerful tool to silence gene expression in multiple organisms. In mammalian cells, duplexes of 21 nucleotide RNAs, known as short-interfering RNAs (siRNAs), efficiently inhibit gene expression. Recent research demonstrates the general use of siRNAs to specifically inhibit HIV-1 replication by targeting viral or cellular genes. Importantly, RNAi opens a new avenue for gene-based therapeutics.

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Gene SilencingGenetic TherapyHIV InfectionsHIV-1HumansRNA InterferenceVirus ReplicationNewsResearch Support, Non-U.S. Gov't

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Miguel Angel Martínez, Bonaventura Clotet, José A Esté. 2002. RNA interference of HIV replication.. https://doi.org/10.1016/s1471-4906(02)02328-1

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