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Rates of behavior and aging specified by mitochondrial function during development.

Andrew Dillin·Ao-Lin Hsu·Nuno Arantes-Oliveira·Joshua Lehrer-Graiwer·Honor Hsin·Andrew G Fraser·Ravi S Kamath·Julie Ahringer·Cynthia Kenyon
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Abstract

To explore the role of mitochondrial activity in the aging process, we have lowered the activity of the electron transport chain and adenosine 5'-triphosphate (ATP) synthase with RNA interference (RNAi) in Caenorhabditis elegans. These perturbations reduced body size and behavioral rates and extended adult life-span. Restoring messenger RNA to near-normal levels during adulthood did not elevate ATP levels and did not correct any of these phenotypes. Conversely, inhibiting respiratory-chain components during adulthood only did not reset behavioral rates and did not affect life-span. Thus, the developing animal appears to contain a regulatory system that monitors mitochondrial activity early in life and, in response, establishes rates of respiration, behavior, and aging that persist during adulthood.

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AgingAnimalsBehavior, AnimalCaenorhabditis elegansCaenorhabditis elegans ProteinsCell SizeElectron TransportElectron Transport Complex IElectron Transport Complex IIIElectron Transport Complex IVEndoribonucleasesFeeding BehaviorForkhead Transcription FactorsIron-Sulfur ProteinsLongevityMitochondriaMitochondrial Proton-Translocating ATPasesMovementNADH DehydrogenaseNADH, NADPH OxidoreductasesOxygen ConsumptionPhenotypeRNA InterferenceRNA, Double-StrandedRNA, MessengerReceptor, InsulinRibonuclease IIITranscription FactorsJournal ArticleResearch Support, Non-U.S. Gov't

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Andrew Dillin, Ao-Lin Hsu, Nuno Arantes-Oliveira, Joshua Lehrer-Graiwer, Honor Hsin, Andrew G Fraser, Ravi S Kamath, Julie Ahringer, Cynthia Kenyon. 2002-12-05. Rates of behavior and aging specified by mitochondrial function during development.. https://doi.org/10.1126/science.1077780

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