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PubMed · 124793

[Depression of contractile function and decrease of the effectiveness of oxygen utilization during compensatory heart hypertrophy].

F Z Meerson·N P Larionov
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Abstract

Heart hypertrophy was produced in rats by creating a coarctation of the aorta 4 months prior to the experiment. The conducted study of the contractile function and oxygen consumption in isolated working hearts demonstrated a marked decrease in the contractile function of the hypertrophied hearts, as compared to the intact ones. Oxygen utilization, however, remained in these preparations equal to that in the controls: hence, the efficacy of oxygen utilization per unit of function was decreased. At the same time, the process of mobilization--glycogen re-synthesis--is highly activated, and glycolysis--accelerated. In order to explain these phenomena it was postulated that the falling efficacy of oxygen utilization and glycogenolysis activation may be caused by a growing calcium concentration in the myoplasm due to the progressive decrease of the capacity of the calcium pump of the sarcoplasmatic reticulum in the process of heart hypertrophy development.

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AnimalsCardiomegalyGlycogenHeartMaleMyocardial ContractionMyocardiumOxygen ConsumptionRatsEnglish AbstractJournal Article

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F Z Meerson, N P Larionov. 1975. [Depression of contractile function and decrease of the effectiveness of oxygen utilization during compensatory heart hypertrophy].. https://pubmed.ncbi.nlm.nih.gov/124793/

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