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PubMed · 12485931

Intercellular adhesion molecule-1 in the heart.

Hans W M Niessen·Paul A J Krijnen·Cees A Visser·Chris J L M Meijer·C Erik Hack
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Abstract

Intercellular adhesion molecule-1 (ICAM-1) belongs to the superfamily of immunoglobulin-like adhesion molecules. Up-regulation of ICAM-1 occurs in many different pathophysiological processes. Also, cardiomyocytes can express ICAM-1-for example, in acute myocardial infarction. Moreover, inhibition of ICAM-1 expression in the heart dramatically reduces infarct size. Hence, inhibitors of ICAM-1 may provide a novel therapeutic option for acute myocardial infarction.

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AnimalsCell AdhesionCell LineGene Expression RegulationHeartHumansIntercellular Adhesion Molecule-1Myocardial InfarctionMyocardiumTranscription FactorsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Hans W M Niessen, Paul A J Krijnen, Cees A Visser, Chris J L M Meijer, C Erik Hack. 2002. Intercellular adhesion molecule-1 in the heart.. https://doi.org/10.1111/j.1749-6632.2002.tb04703.x

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