Inflammation in atherosclerosis.

Peter Libby

doi:10.1038/nature01323

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PubMed · 12490960

Inflammation in atherosclerosis.

Peter Libby

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Abstract

Abundant data link hypercholesterolaemia to atherogenesis. However, only recently have we appreciated that inflammatory mechanisms couple dyslipidaemia to atheroma formation. Leukocyte recruitment and expression of pro-inflammatory cytokines characterize early atherogenesis, and malfunction of inflammatory mediators mutes atheroma formation in mice. Moreover, inflammatory pathways promote thrombosis, a late and dreaded complication of atherosclerosis responsible for myocardial infarctions and most strokes. The new appreciation of the role of inflammation in atherosclerosis provides a mechanistic framework for understanding the clinical benefits of lipid-lowering therapies. Identifying the triggers for inflammation and unravelling the details of inflammatory pathways may eventually furnish new therapeutic targets.

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Animals Arteriosclerosis Chemotaxis, Leukocyte Disease Susceptibility Humans Inflammation Leukocytes Risk Tunica Intima Journal Article Review

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Peter Libby. Inflammation in atherosclerosis.. https://doi.org/10.1038/nature01323

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