InterPreTS: protein interaction prediction through tertiary structure.

Patrick Aloy; Robert B Russell

doi:10.1093/bioinformatics/19.1.161

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InterPreTS: protein interaction prediction through tertiary structure.

Patrick Aloy·Robert B Russell

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Abstract

SUMMARY: InterPreTS (Interaction Prediction through Tertiary Structure) is a web-based version of our method for predicting protein-protein interactions (Aloy and Russell, 2002, PROC: Natl Acad. Sci. USA, 99, 5896-5901). Given a pair of query sequences, we first search for homologues in a database of interacting domains (DBID) of known three-dimensional complex structures. Pairs of sequences homologous to a known interacting pair are scored for how well they preserve the atomic contacts at the interaction interface. InterPreTS includes a useful interface for visualising molecular details of any predicted interaction. AVAILABILITY: http://www.russell.embl.de/interprets.

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Databases, Protein Imaging, Three-Dimensional Macromolecular Substances Protein Binding Protein Interaction Mapping Protein Structure, Tertiary Proteins Sequence Alignment Sequence Homology, Amino Acid User-Computer Interface Journal Article

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Patrick Aloy, Robert B Russell. 2003. InterPreTS: protein interaction prediction through tertiary structure.. https://doi.org/10.1093/bioinformatics%2F19.1.161

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