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Chondromodulin I is a bone remodeling factor.

Yuko Nakamichi·Chisa Shukunami·Takashi Yamada·Ken-ichi Aihara·Hirotaka Kawano·Takashi Sato·Yuriko Nishizaki·Yoko Yamamoto·Masayo Shindo·Kimihiro Yoshimura·Takashi Nakamura·Naoyuki Takahashi·Hiroshi Kawaguchi·Yuji Hiraki·Shigeaki Kato
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Abstract

Chondromodulin I (ChM-I) was supposed from its limited expression in cartilage and its functions in cultured chondrocytes as a major regulator in cartilage development. Here, we generated mice deficient in ChM-I by targeted disruption of the ChM-I gene. No overt abnormality was detected in endochondral bone formation during embryogenesis and cartilage development during growth stages of ChM-I(-/-) mice. However, a significant increase in bone mineral density with lowered bone resorption with respect to formation was unexpectedly found in adult ChM-I(-/-) mice. Thus, the present study established that ChM-I is a bone remodeling factor.

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AllelesAnimalsAnimals, NewbornBlotting, NorthernBlotting, SouthernBlotting, WesternBone DevelopmentBone Marrow CellsCartilageCells, CulturedFemaleHomozygoteIntercellular Signaling Peptides and ProteinsMacrophagesMaleMembrane ProteinsMiceMice, Inbred C57BLMice, TransgenicModels, GeneticOsteoblastsRNA, MessengerRecombination, GeneticReverse Transcriptase Polymerase Chain ReactionJournal ArticleResearch Support, Non-U.S. Gov't

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Yuko Nakamichi, Chisa Shukunami, Takashi Yamada, Ken-ichi Aihara, Hirotaka Kawano, Takashi Sato, Yuriko Nishizaki, Yoko Yamamoto, Masayo Shindo, Kimihiro Yoshimura, Takashi Nakamura, Naoyuki Takahashi, Hiroshi Kawaguchi, Yuji Hiraki, Shigeaki Kato. 2003. Chondromodulin I is a bone remodeling factor.. https://doi.org/10.1128/mcb.23.2.636-644.2003

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