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PubMed · 12510397

[Sequential analysis in clinical and epidemiological research].

I van der Tweel·M Schipper
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Abstract

In clinical trials and epidemiological studies, interim analyses are usually performed for ethical or economical reasons, although efficiency aspects can also be a reason. The analysis is referred to as group-sequential analysis or continuous-sequential analysis, dependent on the number of interim analyses performed. Repeated testing of cumulative data requires an adjustment to the significance level or type I error alpha of a statistical test. On average a (group-)sequential analysis of a clinical or epidemiological study requires less patients than the analysis of a fixed-sample study.

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Clinical Trials as TopicData Interpretation, StatisticalEpidemiologic StudiesHumansResearch DesignSample SizeEnglish AbstractJournal ArticleReview

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I van der Tweel, M Schipper. 2002-12-07. [Sequential analysis in clinical and epidemiological research].. https://pubmed.ncbi.nlm.nih.gov/12510397/

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