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PubMed · 12515077

Antiangiogenesis agents.

Antonio P Ciardella·Irene M Donsoff·David R Guyer·Anthony Adamis·Lawrence A Yannuzzi
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Abstract

Although these preliminary results on the use of antiangiogenesis drugs for the treatment of neovascular AMD appear promising, double-masked, placebo-controlled, multicenter clinical trials are needed to demonstrate the therapeutic efficacy of such treatments. For example, the first antiangiogenesis drug tested in AMD, interferon alpha-2a, raised great enthusiasm. Indeed, interferon alpha-2a had been shown to be antiangiogenic in animal and in vitro models. It proved to be ineffective, however, in halting the progression of neovascular AMD in a double-masked, placebo-controlled clinical trial [28]. Another antivasogenesis drug tested in a phase 3 clinical trial is thalidomide [67]. Although the enrollment of patients is finished, the results are not yet known.

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Angiogenesis InhibitorsChoroidal NeovascularizationClinical Trials as TopicHumansInterferon alpha-2Interferon-alphaMacular DegenerationRecombinant ProteinsThalidomideJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Antonio P Ciardella, Irene M Donsoff, David R Guyer, Anthony Adamis, Lawrence A Yannuzzi. 2002. Antiangiogenesis agents.. https://doi.org/10.1016/s0896-1549(02)00042-1

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The immunosuppressant FTY720 inhibits tumor angiogenesis via the sphingosine 1-phosphate receptor 1.

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Angiogenesis Inhibitors↗