A plus-end raft to control microtubule dynamics and function.

Niels Galjart; Franck Perez

doi:10.1016/s0955-0674(02)00007-8

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PubMed · 12517703

A plus-end raft to control microtubule dynamics and function.

Niels Galjart·Franck Perez

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Abstract

Cells require a properly oriented and organised microtubule array to transmit positional information. Recent data have revealed a heterogeneous population of microtubule-binding proteins that accumulates mainly at distal ends of polymerising microtubules. Two mechanisms may account for this concentration: transient immobilisation, which involves association of proteins with growing ends, followed by release more proximally; and deposition at ends via a molecular motor. As with lipid rafts, protein concentration at distal ends may allow a cascade of interactions in the restricted area of a microtubule plus end. This may, in turn, control the dynamic behaviour of this cytoskeletal network and its anchoring to other structures.

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Animals Cell Polarity Eukaryotic Cells Humans Macromolecular Substances Microtubule Proteins Microtubules Molecular Motor Proteins Protein Binding Protein Structure, Tertiary Journal Article Review

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Niels Galjart, Franck Perez. 2003. A plus-end raft to control microtubule dynamics and function.. https://doi.org/10.1016/s0955-0674(02)00007-8

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